Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Sinclair Method: A Revolutionary Approach to Alcohol Harm Reduction
The Sinclair Method (TSM) is an evidence-based treatment for Alcohol Use Disorder (AUD) that diverges from traditional abstinence-focused approaches. Developed by Dr. John David Sinclair, TSM employs the opioid antagonist naltrexone to disrupt the brain's association between alcohol consumption and pleasurable sensations. This process, known as pharmacological extinction, gradually diminishes the desire to drink.
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